Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells

Cell contractility is mainly imagined as a force dipole-like interaction based on actin stress fibers that pull cellular adhesion sites. Here, we present different type of isotropic contractions within the actomyosin cortex. Measuring mechanosensitive cortical suspended cells among various cell lines allowed us to exclude effects caused by fibers. We found epithelial display higher tension than mesenchymal cells, directly contrasting fiber-mediated contractility. These two types can even be used distinguish from cells. findings single level correlate rearrangement cortices assembled in multicellular aggregates. Epithelial form collective contractile cortex surrounding aggregates and further generate high surface reminiscent tissue boundaries. Hence, suggest this intercellular structure crucial for integrity. In contrast, do not reducing cohesion enabling escape